The increasing prevalence of multidrug-resistant Klebsiella pneumoniae strains isolated from hospitals shows the limitation of\nrecent antibiotics used for bacterial eradication. In this study, 81 K. pneumoniae isolates were collected from three hospitals in\nTehran. Antibiotic susceptibility test showed the highest rates of resistance to cefotaxim (85.5%) and ceftazidime (78.3%), and the\nlowest rates of resistance were detected for colistin (16.9%), streptomycin (16.8%), and chloroamphenicol (21.7%). Eleven different\nresistance patterns were observed. Sixty-six out of 81 isolates (81.5%) were found to be multidrug resistant (MDR), and 35.8% of\nthem belonged to A3 resistance pattern. 7.4% and 66.7% were KPC enzyme and armA gene positive, respectively. RAPD PCR\nassay of these bacteria showed 5 clusters, 16 single types, and 14 common types, and there was not any correlation between genetic\npatterns of the isolates and presence of resistance agents. Simultaneous detection of resistance-creating agents could be an\nimportant challenge for combination therapy of MDR K. pneumoniae-caused infections
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